多管道寡核甘酸合成方法及裝置

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

090105888

專利證號

I232867

專利獲證名稱

多管道寡核甘酸合成方法及裝置

專利所屬機關 (申請機關)

中央研究院

獲證日期

2005/05/21

技術說明

We have constructed a multiplex oligonucleotide synthesizer capable of producing 24, 48, 96, or 384 oligonucleotides by microplate format at a time. The synthesis format and the number of channel are easily changeable. With the 384-channel format, 384 oligonucleotides of 20-mer in length can be synthesized in less than 10 hours. For each oligonucleotide, 5-20 nmol is prepared. Currently the synthesis step yield is greater than 99 %. The product purity and quality are evaluated by CE and UV-Vis spectrophotometer. The accuracy of the oligonucleotide synthesis has been verified by PCR and Southern hybridization experiments.

備註

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02-2787-2508

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