胜肽組合物及其用途

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

106113009

專利證號

I 624477

專利獲證名稱

胜肽組合物及其用途

專利所屬機關 (申請機關)

東海大學

獲證日期

2018/05/21

技術說明

The Heart Protection Effect of Alcalase Potato Protein Hydrolysate and pure peptides are through IGF1R-PI3K-Akt Compensatory Reactivation in Aging Rats on High Fat Diets The prevalence of obesity is high in older adults. Alcalase potato protein hydrolysate (APPH) and pure peptides, a nutraceutical food, might have greater benefits and be more economical than hypolipidemic drugs. In this study, serum lipid profiles and heart protective effects were evaluated in high fat diet (HFD) induced hyperlipidemia in aging rats treated with APPH (15, 45 and 75 mg/kg/day) and probucol (500 mg/kg/day). APPH treatments reduced serum triacylglycerol (TG), total cholesterol (TC), and low density lipoprotein (LDL) levels to the normal levels expressed in the control group. Additionally, the IGF1R-PI3K-Akt survival pathway was reactivated, and Fas-FADD (Fas-associated death domain) induced apoptosis was inhibited by APPH treatments (15 and 45 mg/kg/day) in HFD aging rat hearts. APPH (75 mg/kg/day) rather than probucol (500 mg/kg/day) treatment could reduce serum lipids without affecting HDL expression. The heart protective effect of APPH in aging rats with hyperlipidemia was through lowering serum lipids and enhancing the activation of the compensatory IGF1R-PI3K-Akt survival pathway. Alcalase馬鈴薯蛋白水解產物及胜肽對高脂飲食的老化大鼠的保護作用是透過過IGF1R-PI3K-Akt補償性激活途徑產生來顯現的。 肥胖的患病率在老年人中較高。營養食品Alcalase馬鈴薯蛋白水解物（APPH）及其胜肽可能比降血脂藥具有更大的益處，並且更經濟。在這項研究中，評估了高脂飲食（HFD）引起的高脂血症的高脂飲食（APPH（15、45和75 mg / kg /天）和降血脂藥probucol（500 mg / kg /天） 。 APPH治療可將血清三酸甘油脂（TG），總膽固醇（TC）和低密度脂蛋白（LDL）水平降低至對照組中表達的正常水平。此外，IGF1R-PI3K-Akt生存途徑被重新激活，並且Fas-FADD（Fas-associated在HFD老化大鼠心臟中，APPH處理（分別為15和45 mg / kg /天）可抑制細胞死亡（死亡域）誘導的凋亡。 APPH（75 mg / kg /天）而不是降血脂藥probucol（500 mg / kg /天）治療可以減少血脂而不影響HDL表達。 APPH及其胜肽對高脂血症衰老大鼠的心臟保護作用是通過降低血脂和增強代償性IGF1R-PI3K-Akt生存途徑的激活來呈現保護作用。

備註

連絡單位 (專責單位/部門名稱)

研發處

連絡電話

04-23594711

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