以溫感水膠製備含多孔性陶瓷組合物的方法Method for preparing composition comprising porous ceramic with thermo-response hydrogel

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

13/080,960

專利證號

US 8,940,203 B2

專利獲證名稱

以溫感水膠製備含多孔性陶瓷組合物的方法Method for preparing composition comprising porous ceramic with thermo-response hydrogel

專利所屬機關 (申請機關)

高雄醫學大學

獲證日期

2015/01/27

技術說明

本發明欲發展具奈/微米孔隙之多孔性磷酸鈣鹽生物陶瓷複合材料支架（scaffold），使得體液中養分與新生血管能適時進入此多孔性磷酸鈣鹽生物陶瓷支架中，並達到良好多孔性、製程簡易性且在體內具有部分可吸收性，將來並可與抗發炎或促進骨生長的藥物進行包埋或接枝。故本發明以溫感水膠模板進行多孔性與製程簡易開發，並以雙相磷酸鹽生物陶瓷結構成份來增加生物吸收性。此生物材料使用時尚可與骨髓混合以利用骨髓之骨誘導（osteo-induction）與骨生成（osteo-genesis）之效果而促進骨再生。發明人發現到使用溫感水膠製備多孔性陶瓷有許多優點，如（1）溫感水膠在溫度上升時會有收縮的能力，讓燒結粉體能構緻密化；（2）室溫時溫感水膠為液狀，可進行室溫攪拌製程；（3）溫感水膠不會對羥基磷灰石（HAp）燒結產生相轉變或是細胞毒性；（4）溫感水膠有器孔殘留與微小孔的模板功能；及（5）可再添加第二類成孔劑來製備多孔性。 porous bioceramic acts as a scaffold for the rapid ingrowths of vascularized connective tissue and bone. According to the current literature the optimal pore size is estimated to be 80~1603 or 500~1000 m4. Besides the strength acts the performance of porous hydroxyapatite ceramics. However, the compressive strength of cancellous bone will be ~5 MPa. Several technologies exist today to manufacture strong and reliable porous ceramics. But these scaffolds prepared methods maybe can have a controllable pore size, interconnected pores, and desired geometry but often poor mechanical strength for load-bearing applications. The hypothesis is that thermo-responsive hydrogel will shrink with the temperature increasing. In this study, we report a novel technique that integrates the thermo-responsive hydrogel technique with Polyethylene (PE) powder porogen method to prepare porous bioceramic with improved mechanical strength.

備註

連絡單位 (專責單位/部門名稱)

智財保護與科技管理組

連絡電話

07-3138030

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