3-PED4HPT衍生物之合成與抗光老化活性之評估

專利類型

發明

專利國別 (專利申請國家)

中華民國

專利申請案號

101125690

專利證號

I 619710

專利獲證名稱

3-PED4HPT衍生物之合成與抗光老化活性之評估

專利所屬機關 (申請機關)

高雄醫學大學

獲證日期

2018/04/01

技術說明

本發明揭示一種用於處理皮膚光老化且包含式I三唑衍生物之醫藥組合物，以及式I三唑衍生物之製備方法，其係以式II起始物與氯化鋅反應而得。式II起始物及式I衍生物的R1、R2與R3可分別為氫、鹵素、甲基、乙基、硝基、甲氧基、氨基或三鹵甲基等基團，且n為1或2。式I衍生物能抑制紫外光A引起的皮膚纖維母細胞之傷害，降低纖維母細胞的ROS、MMP-1及/或SA--Gal表現量，及/或提高ATP、粒線體膜電位、TIMP-1及/或COL11表現量。因此式I衍生物具有處理、治療、改善皮膚光老化的潛能，而應用於醫療、醫學美容、美容、護膚、調理膚質、化妝品、彩妝產品等產業上。 Disclosed herein are a pharmaceutical composition for treating the premature aging of skin (photoaging) and including a triazole derivative of formula I, as well as the preparation method of the derivative of formula I. The method is performed by reacting a starting material of formula II with ZnCl2 to afford the derivative of formula I. Each of R1, R2 and R3 in formulas I and II may be the moiety, such as –H, –X, –CH3, –C2H5, –NO2, –OCH3, –NH2 and –CX3, and n denotes to 1 or 2. Derivatives of formula I can suppress UVA-induced damage in fibroblasts, decrease the levels of ROS, MMP-1 and/or SA--Gal, and/or increase the levels of ATP, mitochondrial membrane potential, TIMP-1 and/or COL11 in fibroblasts. Therefore, derivatives of formula I have the potential in the treatment, therapy and improvement on photoaging, and can be applied in industries, such as medical treatment, medical cosmetics, beauty, skin care, skin recuperation, cosmetics and color cosmetics, for example.

備註

連絡單位 (專責單位/部門名稱)

智財保護與科技管理組

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07-3138030

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