發明
日本
特願 2020-131807
特許 7010516
用於辨別癌細胞部位及病變程度的生物感測晶片及其方法 「癌細胞部位と病変の程度を識別するためのバイオセンサチップ及びその方法」
國立中正大學
2022/01/17
本發明以矽太陽能元件之吸光層結合鋸齒狀指叉式電極(Serrated Interdigitated Electrode, SIE),使用四種不同類型的癌細胞臨床樣品,分別為CE81T食道癌細胞、OE21食道癌細胞、A549肺腺癌細胞、TSGH-8301膀胱癌細胞,我們以鋸齒狀指叉式電極透過介電泳阻抗量測對癌細胞進行聚集和阻抗分析,並以此方式辨別不同部位之癌細胞且透過太陽能元件之吸光層以光激載子方式使電子電洞對分離,利用GSH、GSSG之濃度催化機制進行光電流響應量並辨別相同部位不同癌病變程度之癌細胞臨床樣品。 The invention discloses the light-absorbing layer of the solar element was combined with the SIE(Serrated Interdigitated Electrode), and four different types of cancer cell clinical samples were used, namely CE81T esophageal cancer cells, OE21 esophageal cancer cells, A549 lung adenocarcinoma cells, TSGH-8301 bladder cancer cells, we used a zigzag-toothed electrode to measure the aggregation and impedance of cancer cells by means of dielectrophoresis impedance measurement, and in this way, distinguish cancer cells in different parts and pass the light-absorbing layer of the solar element to the photo-activated carrier. The method is to separate the electron hole pair, and use the concentration catalytic mechanism of GSH and GSSG to carry out the photocurrent response amount and discriminate the cancer cell clinical samples of different cancerous lesions in the same site.
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