以核仁磷酸蛋白/B23結合胜肱抑制腫瘤生長並調控P53轉錄活性Nucleophosmin/B23-binding peptide to inhibit tumor growth and regulate transcriptional activity of p53

專利類型

發明

專利國別 (專利申請國家)

美國

專利申請案號

11/239,032

專利證號

US 7,439,223 B2

專利獲證名稱

以核仁磷酸蛋白/B23結合胜肱抑制腫瘤生長並調控P53轉錄活性Nucleophosmin/B23-binding peptide to inhibit tumor growth and regulate transcriptional activity of p53

專利所屬機關 (申請機關)

長庚大學

獲證日期

2008/10/21

技術說明

無 The Rev peptide that binds to nuclephosmin/B23 with the highest affinity exhivits the geatest cytotoxicity on Ras-3T3 cells and inhibits tumor growth most effectively in nude mice. The efficiency of colony formation in soft agar of Ras-3T3 cells is significantly inhibited by treatment with Rev peptide. In addition, Rev peptide can potentiate the doxorubicin-induced decrease of cellular viability in U1 bladder cancer cells and inhibition of tumor growth in nude mice. Treatment of Rev petide increases protein expression and transcriptional activity of p53 and inhibits the nucleophosmin/B23-mediated PCNA

備註

本部(收文號1050015995)同意該校105年2月26日長庚大字第1050020336號函申請終止維護專利

連絡單位 (專責單位/部門名稱)

技術移轉中心

連絡電話

03-2118800轉3201

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